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ATR prevents Ca(2+) overload‐induced necrotic cell death through phosphorylation‐mediated inactivation of PARP1 without DNA damage signaling
Hyperactivation of PARP1 is known to be a major cause of necrotic cell death by depleting NAD(+)/ATP pools during Ca(2+) overload which is associated with many ischemic diseases. However, little is known about how PARP1 hyperactivity is regulated during calcium overload. In this study we show that A...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252533/ https://www.ncbi.nlm.nih.gov/pubmed/33811702 http://dx.doi.org/10.1096/fj.202001636RRR |