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Constant regulation for stable CD8 T‐cell functional avidity and its possible implications for cancer immunotherapy
The functional avidity (FA) of cytotoxic CD8 T cells impacts strongly on their functional capabilities and correlates with protection from infection and cancer. FA depends on TCR affinity, downstream signaling strength, and TCR affinity‐independent parameters of the immune synapse, such as costimula...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252569/ https://www.ncbi.nlm.nih.gov/pubmed/33704770 http://dx.doi.org/10.1002/eji.202049016 |