Cargando…

Constant regulation for stable CD8 T‐cell functional avidity and its possible implications for cancer immunotherapy

The functional avidity (FA) of cytotoxic CD8 T cells impacts strongly on their functional capabilities and correlates with protection from infection and cancer. FA depends on TCR affinity, downstream signaling strength, and TCR affinity‐independent parameters of the immune synapse, such as costimula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gilfillan, Connie B., Hebeisen, Michael, Rufer, Nathalie, Speiser, Daniel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Highlights
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252569/ https://www.ncbi.nlm.nih.gov/pubmed/33704770 http://dx.doi.org/10.1002/eji.202049016

Ejemplares similares

Murine CD8 T‐cell functional avidity is stable in vivo but not in vitro: Independence from homologous prime/boost time interval and antigen density
por: Gilfillan, Connie B., et al.
Publicado: (2019)

Heterogeneity assessment of functional T cell avidity
por: Ioannidou, Kalliopi, et al.
Publicado: (2017)

Identifying Individual T Cell Receptors of Optimal Avidity for Tumor Antigens
por: Hebeisen, Michael, et al.
Publicado: (2015)

Identification and isolation of high avidity tumor-specific CD8 T cells by experimentally assessing pMHC-TCR binding parameters with soluble pMHC complexes
por: Schmidt, Julien, et al.
Publicado: (2015)

Overall avidity declines in TCR repertoires during latent CMV but not EBV infection
por: Couturaud, Barbara, et al.
Publicado: (2023)

Neoantigen-specific CD8 T cells with high structural avidity preferentially reside in and eliminate tumors
por: Schmidt, Julien, et al.
Publicado: (2023)

Transcriptional suppression of CD8(+) T cell exhaustion for improving T cell immunotherapy
por: Yang, Xue, et al.
Publicado: (2021)

Chronic TCR-MHC (self)-interactions limit the functional potential of TCR affinity-increased CD8 T lymphocytes
por: Duong, Minh Ngoc, et al.
Publicado: (2019)

CD8 T cell function and cross-reactivity explored by stepwise increased peptide-HLA versus TCR affinity
por: Baumgaertner, Petra, et al.
Publicado: (2022)

High Peptide Dose Vaccination Promotes the Early Selection of Tumor Antigen-Specific CD8 T-Cells of Enhanced Functional Competence
por: Carretero-Iglesia, Laura, et al.
Publicado: (2020)

From Tpex to Tex: a journey through CD8(+) T cell responses in cancer immunotherapy
por: Messmer, Julia M., et al.
Publicado: (2023)

Metabolic dynamics instruct CD8(+) T‐cell differentiation and functions
por: Bevilacqua, Alessio, et al.
Publicado: (2022)

Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment
por: Multhoff, Gabriele, et al.
Publicado: (2021)

Intestinal CD8(+) tissue‐resident memory T cells: From generation to function
por: Cheng, Liqing, et al.
Publicado: (2022)

AMPKα1: A glucose sensor that controls CD8 T-cell memory
por: Rolf, Julia, et al.
Publicado: (2013)

Multiple sclerosis: Immunopathological heterogeneity and its implications
por: Engelhardt, Britta, et al.
Publicado: (2022)

Peripheral and systemic antigens elicit an expandable pool of resident memory CD8(+) T cells in the bone marrow
por: Pascutti, Maria Fernanda, et al.
Publicado: (2019)

Memory CD8(+) T cells colocalize with IL-7(+) stromal cells in bone marrow and rest in terms of proliferation and transcription
por: Sercan Alp, Özen, et al.
Publicado: (2015)

High hopes and high honours for cancer immunotherapy
por: Häfner, Sophia Julia
Publicado: (2019)

Tumor‐derived microparticles in tumor immunology and immunotherapy
por: Ma, Jingwei, et al.
Publicado: (2020)

CD5: from antiquated T cell marker to immunotherapy’s new hope
por: Schwarz, Sandra, et al.
Publicado: (2023)

Tumor-draining lymph node-derived tumor-specific memory CD8(+) T cells: a key player in PD-1/PD-L1 immunotherapy
por: Yin, Enzhi, et al.
Publicado: (2023)

A new way to maintain CD8(+) T-cell quiescence: interaction between CD8α and PILRα
por: Jin, Ke, et al.
Publicado: (2022)

Targeting FMRP: A new window for cancer immunotherapy
por: Zhang, Yaguang, et al.
Publicado: (2023)

Molecular Insights for Optimizing T Cell Receptor Specificity Against Cancer
por: Hebeisen, Michael, et al.
Publicado: (2013)

Population dynamics of the human gut microbiome: change is the only constant
por: Priya, Sambhawa, et al.
Publicado: (2019)

Antigen targeting to dendritic cells: Still a place in future immunotherapy?
por: Stoitzner, Patrizia, et al.
Publicado: (2022)

MAIT cells boost adenovirus-induced CD8(+) T cells
por: Flemming, Alexandra
Publicado: (2021)

AFM13: a first-in-class tetravalent bispecific anti-CD30/CD16A antibody for NK cell-mediated immunotherapy
por: Wu, Jingjing, et al.
Publicado: (2015)

Mechanism of action of PD‐1 receptor/ligand targeted cancer immunotherapy [Image: see text]
por: Borst, Jannie, et al.
Publicado: (2021)

Unconventional CD45RA+ memory CD8 T cells to control HIV infection during antiretroviral therapy
por: Rolot, Marion, et al.
Publicado: (2020)

Fine-Tuning of Optimal TCR Signaling in Tumor-Redirected CD8 T Cells by Distinct TCR Affinity-Mediated Mechanisms
por: Presotto, Danilo, et al.
Publicado: (2017)

Seedy CD8+ T(RM) cells in aging lungs drive susceptibility to pneumonia and sequelae
por: Shenoy, Anukul T., et al.
Publicado: (2021)

Sensitive and frequent identification of high avidity neo-epitope specific CD8(+) T cells in immunotherapy-naive ovarian cancer
por: Bobisse, Sara, et al.
Publicado: (2018)

“Moonlighting” at the power plant: how mitochondria facilitate serial killing by CD8(+) cytotoxic T cells
por: Mougiakakos, Dimitrios, et al.
Publicado: (2021)

Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitors
por: Baik, Song, et al.
Publicado: (2013)

Metabolic interaction: tumor-derived lactate inhibiting CD8(+) T cell cytotoxicity in a novel route
por: Wang, Ke, et al.
Publicado: (2023)

Rescuing the Golgi from heat damages by ATG8: restoration rather than clean-up
por: Luo, Anni, et al.
Publicado: (2023)

Low Avidity T Cells Do Not Hinder High Avidity T Cell Responses Against Melanoma
por: Ioannidou, Kalliopi, et al.
Publicado: (2019)

An animated landscape representation of CD4(+) T-cell differentiation, variability, and plasticity: Insights into the behavior of populations versus cells
por: Rebhahn, Jonathan A, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_j64toqimbqqhvsj8n16hg85pff