Enantioselective Synthesis of α‐Aryl‐β(2)‐Amino‐Esters by Cooperative Isothiourea and Brønsted Acid Catalysis

The synthesis of α‐aryl‐β(2)‐amino esters through enantioselective aminomethylation of an arylacetic acid ester in high yields and enantioselectivity via cooperative isothiourea and Brønsted acid catalysis is demonstrated. The scope and limitations of this process are explored (25 examples, up to 94...

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Detalles Bibliográficos
Autores principales: Zhao, Feng, Shu, Chang, Young, Claire M., Carpenter‐Warren, Cameron, Slawin, Alexandra M. Z., Smith, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252622/
https://www.ncbi.nlm.nih.gov/pubmed/33646631
http://dx.doi.org/10.1002/anie.202016220

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252622/
https://www.ncbi.nlm.nih.gov/pubmed/33646631
http://dx.doi.org/10.1002/anie.202016220

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