Accelerating and de‐risking CMC development with transposon‐derived manufacturing cell lines

The development of highly productive, genetically stable manufacturing cell lines is on the critical path to IND filing for protein‐based biologic drugs. Here, we describe the Leap‐In Transposase® platform, a novel transposon‐based mammalian (e.g., Chinese hamster ovary) cell line development system...

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Detalles Bibliográficos
Autores principales: Rajendran, Sowmya, Balasubramanian, Sowmya, Webster, Lynn, Lee, Maggie, Vavilala, Divya, Kulikov, Nicolay, Choi, Jessica, Tang, Calvin, Hunter, Molly, Wang, Rebecca, Kaur, Harpreet, Karunakaran, Surya, Sitaraman, Varsha, Minshull, Jeremy, Boldog, Ferenc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
ARTICLES
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252637/
https://www.ncbi.nlm.nih.gov/pubmed/33704772
http://dx.doi.org/10.1002/bit.27742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252637/
https://www.ncbi.nlm.nih.gov/pubmed/33704772
http://dx.doi.org/10.1002/bit.27742

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