Synthesis and in Vitro Evaluation of Novel 5‐Nitroindole Derivatives as c‐Myc G‐Quadruplex Binders with Anticancer Activity

Lead‐optimization strategies for compounds targeting c‐Myc G‐quadruplex (G4) DNA are being pursued to develop anticancer drugs. Here, we investigate the structure‐activity‐ relationship (SAR) of a newly synthesized series of molecules based on the pyrrolidine‐substituted 5‐nitro indole scaffold to t...

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Detalles Bibliográficos
Autores principales: Nimbarte, Vijaykumar D., Wirmer‐Bartoschek, Julia, Gande, Santosh L., Alshamleh, Islam, Seibert, Marcel, Nasiri, Hamid Reza, Schnütgen, Frank, Serve, Hubert, Schwalbe, Harald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252724/
https://www.ncbi.nlm.nih.gov/pubmed/33508167
http://dx.doi.org/10.1002/cmdc.202000835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252724/
https://www.ncbi.nlm.nih.gov/pubmed/33508167
http://dx.doi.org/10.1002/cmdc.202000835

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