Avidity optimization of a MAGE‐A1‐specific TCR with somatic hypermutation

A T‐cell receptor (TCR) with optimal avidity to a tumor antigen can be used to redirect T cells to eradicate cancer cells via adoptive cell transfer. Cancer testis antigens (CTAs) are attractive targets because they are expressed in the testis, which is immune‐privileged, and in the tumor. However,...

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Detalles Bibliográficos
Autores principales: Bassan, David, Gozlan, Yosi Meir, Sharbi‐Yunger, Adi, Tzehoval, Esther, Greenstein, Erez, Bitan, Lidor, Friedman, Nir, Eisenbach, Lea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Immunomodulation and immune therapies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252751/
https://www.ncbi.nlm.nih.gov/pubmed/33835499
http://dx.doi.org/10.1002/eji.202049007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252751/
https://www.ncbi.nlm.nih.gov/pubmed/33835499
http://dx.doi.org/10.1002/eji.202049007

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