Discovery of K(V)1.3 ion channel inhibitors: Medicinal chemistry approaches and challenges

The K(V)1.3 voltage‐gated potassium ion channel is involved in many physiological processes both at the plasma membrane and in the mitochondria, chiefly in the immune and nervous systems. Therapeutic targeting K(V)1.3 with specific peptides and small molecule inhibitors shows great potential for tre...

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Detalles Bibliográficos
Autores principales: Gubič, Špela, Hendrickx, Louise A., Toplak, Žan, Sterle, Maša, Peigneur, Steve, Tomašič, Tihomir, Pardo, Luis A., Tytgat, Jan, Zega, Anamarija, Mašič, Lucija P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Review Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252768/
https://www.ncbi.nlm.nih.gov/pubmed/33932253
http://dx.doi.org/10.1002/med.21800

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252768/
https://www.ncbi.nlm.nih.gov/pubmed/33932253
http://dx.doi.org/10.1002/med.21800

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