Cholesterol and CDON Regulate Sonic Hedgehog Release from Pancreatic Cancer Cells

Background: Sonic Hedgehog (Shh) is a tightly regulated membrane-associated morphogen and a known driver of tumorigenesis in pancreatic ductal adenocarcinoma (PDAC). After processing, Shh remains at the plasma membrane of Shh producing cells, thereby limiting its distribution and signal strength. In...

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Detalles Bibliográficos
Autores principales: Alexander, Jennifer I., Martinez, Esteban, Vargas, Alberto, Zinshteyn, Daniel, Sodi, Valerie, Connolly, Denise C., Hartman, Tiffiney R., O'Reilly, Alana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252898/
https://www.ncbi.nlm.nih.gov/pubmed/34235374
http://dx.doi.org/10.1089/pancan.2021.0002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252898/
https://www.ncbi.nlm.nih.gov/pubmed/34235374
http://dx.doi.org/10.1089/pancan.2021.0002

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