Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling

Pim kinases are upregulated in several forms of cancer, contributing to cell survival and tumor development, but their role in platelet function and thrombotic disease has not been explored. We report for the first time that Pim-1 kinase is expressed in human and mouse platelets. Genetic deletion or...

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Detalles Bibliográficos
Autores principales: Unsworth, Amanda J., Bye, Alexander P., Sage, Tanya, Gaspar, Renato S., Eaton, Nathan, Drew, Caleb, Stainer, Alexander, Kriek, Neline, Volberding, Peter J., Hutchinson, James L., Riley, Ryan, Jones, Sarah, Mundell, Stuart J., Cui, Weiguo, Falet, Hervé, Gibbins, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252961/
https://www.ncbi.nlm.nih.gov/pubmed/32467143
http://dx.doi.org/10.3324/haematol.2019.223529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252961/
https://www.ncbi.nlm.nih.gov/pubmed/32467143
http://dx.doi.org/10.3324/haematol.2019.223529

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