Deletion of IL-4Rα signaling on B cells limits hyperresponsiveness depending on antigen load

BACKGROUND: B cells play an important role in allergies through secretion of IgE. IL-4 receptor α (IL-4Rα) is key in allergic asthma and regulates type 2 cytokine production, IgE secretion, and airway hyperresponsiveness. IL-4 activation of B cells is essential for class switching and contributes to...

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Detalles Bibliográficos
Autores principales: Hadebe, Sabelo, Khumalo, Jermaine, Mangali, Sandisiwe, Mthembu, Nontobeko, Ndlovu, Hlumani, Scibiorek, Martyna, Ngomti, Amkele, Kirstein, Frank, Brombacher, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mosby 2021
Materias:
Asthma and Lower Airway Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253118/
https://www.ncbi.nlm.nih.gov/pubmed/33383090
http://dx.doi.org/10.1016/j.jaci.2020.12.635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253118/
https://www.ncbi.nlm.nih.gov/pubmed/33383090
http://dx.doi.org/10.1016/j.jaci.2020.12.635

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