A T cell redirection platform for co-targeting dual antigens on solid tumors

In order to direct T cells to specific features of solid cancer cells, we engineered a bispecific antibody format, named Dual Antigen T cell Engager (DATE), by fusing a single-chain variable fragment targeting CD3 to a tumor-targeting antigen-binding fragment. In this format, multiple novel paratope...

Descripción completa

Detalles Bibliográficos
Autores principales: Enderle, Leonie, Shalaby, Karim H., Gorelik, Maryna, Weiss, Alexander, Blazer, Levi L., Paduch, Marcin, Cardarelli, Lia, Kossiakoff, Anthony, Adams, Jarrett J., Sidhu, Sachdev S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253144/
https://www.ncbi.nlm.nih.gov/pubmed/34190031
http://dx.doi.org/10.1080/19420862.2021.1933690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253144/
https://www.ncbi.nlm.nih.gov/pubmed/34190031
http://dx.doi.org/10.1080/19420862.2021.1933690

Ejemplares similares