Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine–hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancer

A series of thieno[2,3-d]pyrimidine-based hydroxamic acid hybrids was designed and synthesised as multitarget anti-cancer agents, through incorporating the pharmacophore of EGFR, VEGFR2 into the inhibitory functionality of HDAC6. Three compounds (12c, 15b and 20b) were promising hits, whereas (12c)...

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Detalles Bibliográficos
Autores principales: Abdel-Atty, Mona M., Farag, Nahla A., Serya, Rabah A. T., Abouzid, Khaled A. M., Mowafy, Samar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253220/
https://www.ncbi.nlm.nih.gov/pubmed/34187263
http://dx.doi.org/10.1080/14756366.2021.1933465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253220/
https://www.ncbi.nlm.nih.gov/pubmed/34187263
http://dx.doi.org/10.1080/14756366.2021.1933465

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