TET1 upregulation drives cancer cell growth through aberrant enhancer hydroxymethylation of HMGA2 in hepatocellular carcinoma

Ten‐eleven translocation 1 (TET1) is an essential methylcytosine dioxygenase of the DNA demethylation pathway. Despite its dysregulation being known to occur in human cancer, the role of TET1 remains poorly understood. In this study, we report that TET1 promotes cell growth in human liver cancer. Th...

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Detalles Bibliográficos
Autores principales: Shirai, Kiyokazu, Nagae, Genta, Seki, Motoaki, Kudo, Yotaro, Kamio, Asuka, Hayashi, Akimasa, Okabe, Atsushi, Ota, Satoshi, Tsutsumi, Shuichi, Fujita, Takanori, Yamamoto, Shogo, Nakaki, Ryo, Kanki, Yasuharu, Osawa, Tsuyoshi, Midorikawa, Yutaka, Tateishi, Keisuke, Ichinose, Masao, Aburatani, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253281/
https://www.ncbi.nlm.nih.gov/pubmed/33970549
http://dx.doi.org/10.1111/cas.14897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253281/
https://www.ncbi.nlm.nih.gov/pubmed/33970549
http://dx.doi.org/10.1111/cas.14897

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