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RAG enhances BCR‐ABL1‐positive leukemic cell growth through its endonuclease activity in vitro and in vivo

BCR‐ABL1 gene fusion associated with additional DNA lesions involves the pathogenesis of chronic myelogenous leukemia (CML) from a chronic phase (CP) to a blast crisis of B lymphoid (CML‐LBC) lineage and BCR‐ABL1 (+) acute lymphoblastic leukemia (BCR‐ABL1 (+) ALL). The recombination‐activating gene...

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Detalles Bibliográficos
Autores principales: Yuan, Meng, Wang, Yang, Qin, Mengting, Zhao, Xiaohui, Chen, Xiaodong, Li, Dandan, Miao, Yinsha, Otieno Odhiambo, Wood, Liu, Huasheng, Ma, Yunfeng, Ji, Yanhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253288/
https://www.ncbi.nlm.nih.gov/pubmed/33949040
http://dx.doi.org/10.1111/cas.14939