Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis

BACKGROUND: Long-term hematopoietic stem cells (LT-HSCs) reside in bone marrow niches with tightly controlled reactive oxygen species (ROS) levels. ROS increase results into LT-HSC differentiation and stem cell exhaustion. Paraoxonase 2 (PON2) has been shown to be important for ROS control. OBJECTIV...

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Detalles Bibliográficos
Autores principales: Spiecker, Lisa, Witte, Ines, Mehlig, Julia, Shah, Viral, Meyerhöfer, Markus, Haehnel, Patricia S., Petermann, Victoria, Schüler, Andrea, More, Piyush, Cabezas-Wallscheid, Nina, Horke, Sven, Pautz, Andrea, Daiber, Andreas, Sasca, Daniel, Kindler, Thomas, Kleinert, Hartmut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253644/
https://www.ncbi.nlm.nih.gov/pubmed/34257800
http://dx.doi.org/10.1155/2021/3917028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253644/
https://www.ncbi.nlm.nih.gov/pubmed/34257800
http://dx.doi.org/10.1155/2021/3917028

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