Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway

Gain of even a single chromosome leads to changes in human cell physiology and uniform perturbations of specific cellular processes, including downregulation of DNA replication pathway, upregulation of autophagy and lysosomal degradation, and constitutive activation of the type I interferon response...

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Detalles Bibliográficos
Autores principales: Krivega, Maria, Stiefel, Clara M., Karbassi, Sahar, Andersen, Line L., Chunduri, Narendra K., Donnelly, Neysan, Pichlmair, Andreas, Storchová, Zuzana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253785/
https://www.ncbi.nlm.nih.gov/pubmed/34215848
http://dx.doi.org/10.1038/s42003-021-02278-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253785/
https://www.ncbi.nlm.nih.gov/pubmed/34215848
http://dx.doi.org/10.1038/s42003-021-02278-9

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