Cargando…

Genotoxic stress in constitutive trisomies induces autophagy and the innate immune response via the cGAS-STING pathway

Gain of even a single chromosome leads to changes in human cell physiology and uniform perturbations of specific cellular processes, including downregulation of DNA replication pathway, upregulation of autophagy and lysosomal degradation, and constitutive activation of the type I interferon response...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krivega, Maria, Stiefel, Clara M., Karbassi, Sahar, Andersen, Line L., Chunduri, Narendra K., Donnelly, Neysan, Pichlmair, Andreas, Storchová, Zuzana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253785/ https://www.ncbi.nlm.nih.gov/pubmed/34215848 http://dx.doi.org/10.1038/s42003-021-02278-9

Ejemplares similares

Aneuploidy and proteotoxic stress in cancer
por: Donnelly, Neysan, et al.
Publicado: (2015)

Consequences of Chromosome Loss: Why Do Cells Need Each Chromosome Twice?
por: Chunduri, Narendra Kumar, et al.
Publicado: (2022)

Interplay between RNA viruses and cGAS/STING axis in innate immunity
por: Amurri, Lucia, et al.
Publicado: (2023)

The Innate Immune cGAS-STING-Pathway in Cardiovascular Diseases – A Mini Review
por: Rech, Lavinia, et al.
Publicado: (2021)

How the Innate Immune DNA Sensing cGAS–STING Pathway Is Involved in Autophagy
por: Zheng, Wanglong, et al.
Publicado: (2021)

cGAS/STING and innate brain inflammation following acute high-fat feeding
por: Elzinga, Sarah E., et al.
Publicado: (2022)

How the Innate Immune DNA Sensing cGAS-STING Pathway Is Involved in Apoptosis
por: Zheng, Wanglong, et al.
Publicado: (2023)

ROP16 of Toxoplasma gondii Inhibits Innate Immunity by Triggering cGAS-STING Pathway Inactivity through the Polyubiquitination of STING
por: Jin, Qi-Wang, et al.
Publicado: (2023)

The cGas–Sting Signaling Pathway Is Required for the Innate Immune Response Against Ectromelia Virus
por: Cheng, Wen-Yu, et al.
Publicado: (2018)

Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway
por: Ding, Chunyong, et al.
Publicado: (2020)

The battle between the innate immune cGAS-STING signaling pathway and human herpesvirus infection
por: Jin, Ximing, et al.
Publicado: (2023)

cGAS-STING pathway in cancer biotherapy
por: Wang, Yang, et al.
Publicado: (2020)

Ribonuclease H2 mutations induce a cGAS/STING‐dependent innate immune response
por: Mackenzie, Karen J, et al.
Publicado: (2016)

The Innate Immune DNA Sensing cGAS-STING Signaling Pathway Mediates Anti-PRRSV Function
por: Xu, Yulin, et al.
Publicado: (2021)

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability
por: Hong, Christy, et al.
Publicado: (2019)

cGAS-STING pathway in oncogenesis and cancer therapeutics
por: Hoong, Brandon Yi Da, et al.
Publicado: (2020)

Attenuation of cGAS/STING activity during mitosis
por: Uhlorn, Brittany L, et al.
Publicado: (2020)

The interactions between cGAS-STING pathway and pathogens
por: Cheng, Zhangliang, et al.
Publicado: (2020)

cGAS-STING, an important pathway in cancer immunotherapy
por: Jiang, Minlin, et al.
Publicado: (2020)

The Complexity of the cGAS-STING Pathway in CNS Pathologies
por: Fryer, Amelia L., et al.
Publicado: (2021)

The role of cGAS-STING signalling in liver diseases
por: Chen, Ruihan, et al.
Publicado: (2021)

cGAS/STING: novel perspectives of the classic pathway
por: Gao, Menghui, et al.
Publicado: (2020)

Advances in cGAS-STING Signaling Pathway and Diseases
por: Yang, Yuting, et al.
Publicado: (2022)

Mitotic inactivation of the cGAS‒MITA/STING pathways
por: Zhong, Li, et al.
Publicado: (2021)

Telomere Maintenance and the cGAS-STING Pathway in Cancer
por: Ebata, Hiroshi, et al.
Publicado: (2022)

Intercellular transmission of cGAS-STING signaling in cancer
por: Wu, Qirou, et al.
Publicado: (2023)

Role of cGAS–Sting Signaling in Alzheimer’s Disease
por: Govindarajulu, Manoj, et al.
Publicado: (2023)

The Activation of cGAS-STING in Acute Kidney Injury
por: Sun, Chuanchuan, et al.
Publicado: (2023)

Targeting the loss of cGAS/STING signaling in cancer
por: Sasaki, Nobunari, et al.
Publicado: (2023)

Significance of the cGAS-STING Pathway in Health and Disease
por: Zhou, Jinglin, et al.
Publicado: (2023)

cGAS-STING triggers inflammaging-associated neurodegeneration
por: Izquierdo, José M.
Publicado: (2023)

Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1
por: Maelfait, Jonathan, et al.
Publicado: (2016)

A Bibliometric Analysis of the Innate Immune DNA Sensing cGAS-STING Pathway from 2013 to 2021
por: Shi, Xuan, et al.
Publicado: (2022)

Modeling the innate inflammatory cGAS/STING pathway: sexually dimorphic effects on microglia and cognition in obesity and prediabetes
por: Elzinga, Sarah E., et al.
Publicado: (2023)

Activation of the cGAS-STING innate immune response in cells with deficient mitochondrial topoisomerase TOP1MT
por: Al Khatib, Iman, et al.
Publicado: (2023)

Innate sensing of picornavirus infection involves cGAS-STING-mediated antiviral responses triggered by mitochondrial DNA release
por: Liu, Huisheng, et al.
Publicado: (2023)

Porcine cGAS-STING signaling induced autophagy inhibits STING downstream IFN and apoptosis
por: Xia, Nengwen, et al.
Publicado: (2022)

The cGAS-STING Defense Pathway and Its Counteraction by Viruses
por: Ma, Zhe, et al.
Publicado: (2016)

cGAS-independent STING activation in response to DNA damage
por: Unterholzner, Leonie, et al.
Publicado: (2019)

Conserved strategies for pathogen evasion of cGAS–STING immunity
por: Eaglesham, James B, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_d4et59dsacf6sbj8i1sr5qvhkq