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Tumour-derived exosomal lncRNA-SOX2OT promotes bone metastasis of non-small cell lung cancer by targeting the miRNA-194-5p/RAC1 signalling axis in osteoclasts

Bone is a frequent metastatic site of non-small cell lung cancer (NSCLC), and bone metastasis (BoM) presents significant challenges for patient survival and quality of life. Osteolytic BoM is characterised by aberrant differentiation and malfunction of osteoclasts through modulation of the TGF-β/pTH...

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Detalles Bibliográficos
Autores principales: Ni, Jianjiao, Zhang, Xiaofei, Li, Juan, Zheng, Zhiqin, Zhang, Junhua, Zhao, Weixin, Liu, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253828/
https://www.ncbi.nlm.nih.gov/pubmed/34215717
http://dx.doi.org/10.1038/s41419-021-03928-w