Identification of new GLUT2-selective inhibitors through in silico ligand screening and validation in eukaryotic expression systems

Glucose is an essential energy source for cells. In humans, its passive diffusion through the cell membrane is facilitated by members of the glucose transporter family (GLUT, SLC2 gene family). GLUT2 transports both glucose and fructose with low affinity and plays a critical role in glucose sensing...

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Detalles Bibliográficos
Autores principales: Schmidl, Sina, Ursu, Oleg, Iancu, Cristina V., Oreb, Mislav, Oprea, Tudor I., Choe, Jun-yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253845/
https://www.ncbi.nlm.nih.gov/pubmed/34215797
http://dx.doi.org/10.1038/s41598-021-93063-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253845/
https://www.ncbi.nlm.nih.gov/pubmed/34215797
http://dx.doi.org/10.1038/s41598-021-93063-5

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