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Tribbles homolog 3-mediated targeting the AKT/mTOR axis in mice with retinal degeneration

Various retinal degenerative disorders manifest in alterations of the AKT/mTOR axis. Despite this, consensus on the therapeutic targeting of mTOR in degenerating retinas has not yet been achieved. Therefore, we investigated the role of AKT/mTOR signaling in rd16 retinas, in which we restored the AKT...

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Detalles Bibliográficos
Autores principales: Saltykova, Irina V., Elahi, Asif, Pitale, Priyam M., Gorbatyuk, Oleg S., Athar, Mohammad, Gorbatyuk, Marina S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253859/
https://www.ncbi.nlm.nih.gov/pubmed/34215725
http://dx.doi.org/10.1038/s41419-021-03944-w