Extracellular loops of the serotonin transporter act as a selectivity filter for drug binding

The serotonin transporter (SERT) shapes serotonergic neurotransmission by retrieving its eponymous substrate from the synaptic cleft. Ligands that discriminate between SERT and its close relative, the dopamine transporter DAT, differ in their association rate constant rather than their dissociation...

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Detalles Bibliográficos
Autores principales: Esendir, Eray, Burtscher, Verena, Coleman, Jonathan A., Zhu, Rong, Gouaux, Eric, Freissmuth, Michael, Sandtner, Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253976/
https://www.ncbi.nlm.nih.gov/pubmed/34118233
http://dx.doi.org/10.1016/j.jbc.2021.100863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8253976/
https://www.ncbi.nlm.nih.gov/pubmed/34118233
http://dx.doi.org/10.1016/j.jbc.2021.100863

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