Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia

The contribution of the Ubiquitin-Proteasome System (UPS) to mitophagy has been largely attributed to the E3 ubiquitin ligase Parkin. Here we show that in response to the oxidative stress associated with hypoxia or the hypoxia mimic CoCl(2), the damaged and fragmented mitochondria are removed by Par...

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Detalles Bibliográficos
Autores principales: Sulkshane, Prasad, Ram, Jonathan, Thakur, Anita, Reis, Noa, Kleifeld, Oded, Glickman, Michael H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254004/
https://www.ncbi.nlm.nih.gov/pubmed/34175667
http://dx.doi.org/10.1016/j.redox.2021.102047

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254004/
https://www.ncbi.nlm.nih.gov/pubmed/34175667
http://dx.doi.org/10.1016/j.redox.2021.102047

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