The N-terminal domain of the prion protein is required and sufficient for liquid–liquid phase separation: A crucial role of the Aβ-binding domain

Formation of biomolecular condensates through liquid–liquid phase separation (LLPS) has been described for several pathogenic proteins linked to neurodegenerative diseases and is discussed as an early step in the formation of protein aggregates with neurotoxic properties. In prion diseases, neurodeg...

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Detalles Bibliográficos
Autores principales: Kamps, Janine, Lin, Yu-Hsuan, Oliva, Rosario, Bader, Verian, Winter, Roland, Winklhofer, Konstanze F., Tatzelt, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254114/
https://www.ncbi.nlm.nih.gov/pubmed/34102212
http://dx.doi.org/10.1016/j.jbc.2021.100860

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254114/
https://www.ncbi.nlm.nih.gov/pubmed/34102212
http://dx.doi.org/10.1016/j.jbc.2021.100860

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