The aminosterol Claramine inhibits β-secretase 1–mediated insulin receptor cleavage

The cleavage of the insulin receptor by β-secretase 1 (BACE1) in the liver increases during diabetes, which contributes to reduce insulin receptor levels and impair insulin signaling. However, the precise signaling events that lead to this increased cleavage are unclear. We showed that BACE1 cleaves...

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Detalles Bibliográficos
Autores principales: Gaborit, Bénédicte, Govers, Roland, Altié, Alexandre, Brunel, Jean Michel, Morange, Pierre, Peiretti, Franck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254121/
https://www.ncbi.nlm.nih.gov/pubmed/34029592
http://dx.doi.org/10.1016/j.jbc.2021.100818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254121/
https://www.ncbi.nlm.nih.gov/pubmed/34029592
http://dx.doi.org/10.1016/j.jbc.2021.100818

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