Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains

Neuritic plaques in Alzheimer’s disease (AD) brains refer to β-amyloid (Aβ) plaques surrounded by dystrophic neurites (DNs), activated microglia and reactive astrocytes. Most recently, we showed that DNs form sequentially in three layers during plaque growth. Although lysosomal proteins such as LAMP...

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Detalles Bibliográficos
Autores principales: Sharoar, Md Golam, Palko, Sarah, Ge, Yingying, Saido, Takaomi C., Yan, Riqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254260/
https://www.ncbi.nlm.nih.gov/pubmed/34215298
http://dx.doi.org/10.1186/s13024-021-00464-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254260/
https://www.ncbi.nlm.nih.gov/pubmed/34215298
http://dx.doi.org/10.1186/s13024-021-00464-1

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