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Accumulation of saposin in dystrophic neurites is linked to impaired lysosomal functions in Alzheimer’s disease brains
Neuritic plaques in Alzheimer’s disease (AD) brains refer to β-amyloid (Aβ) plaques surrounded by dystrophic neurites (DNs), activated microglia and reactive astrocytes. Most recently, we showed that DNs form sequentially in three layers during plaque growth. Although lysosomal proteins such as LAMP...
Autores principales: | Sharoar, Md Golam, Palko, Sarah, Ge, Yingying, Saido, Takaomi C., Yan, Riqiang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254260/ https://www.ncbi.nlm.nih.gov/pubmed/34215298 http://dx.doi.org/10.1186/s13024-021-00464-1 |
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