Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury

The STING pathway and its induction of autophagy initiate a potent immune defense response upon the recognition of pathogenic DNA. However, this protective response is minimal, as STING activation worsens organ damage, and abnormal autophagy is observed during progressive sepsis. Whether and how the...

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Detalles Bibliográficos
Autores principales: Liu, Qinjie, Wu, Jie, Zhang, Xufei, Li, Xuanheng, Wu, Xiuwen, Zhao, Yun, Ren, Jianan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254453/
https://www.ncbi.nlm.nih.gov/pubmed/34218252
http://dx.doi.org/10.1038/s41419-021-03961-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254453/
https://www.ncbi.nlm.nih.gov/pubmed/34218252
http://dx.doi.org/10.1038/s41419-021-03961-9

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