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Cell-type specific effects of genetic variation on chromatin accessibility during human neuronal differentiation
Common genetic risk for neuropsychiatric disorders is enriched in regulatory elements active during cortical neurogenesis. However, it remains poorly understood how these variants influence gene regulation. To model the functional impact of common genetic variation on the non-coding genome during hu...
Autores principales: | Liang, Dan, Elwell, Angela L., Aygün, Nil, Krupa, Oleh, Wolter, Justin M., Kyere, Felix A., Lafferty, Michael J., Cheek, Kerry E., Courtney, Kenan P., Yusupova, Marianna, Garrett, Melanie E., Ashley-Koch, Allison, Crawford, Gregory E., Love, Michael I., de la Torre-Ubieta, Luis, Geschwind, Daniel H., Stein, Jason L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254789/ https://www.ncbi.nlm.nih.gov/pubmed/34017130 http://dx.doi.org/10.1038/s41593-021-00858-w |
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