Hunger or thirst state-uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making

Physiological need states direct decision-making towards re-establishing homeostasis. Using a two-alternative-forced-choice task for mice that models elements of human decisions, we found that varying hunger and thirst states caused need-inappropriate choices, such as food-seeking when thirsty. Thes...

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Autores principales: Eiselt, Anne-Kathrin, Chen, Susu, Chen, Jim, Arnold, Jon, Kim, Tahnbee, Pachitariu, Marius, Sternson, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254795/
https://www.ncbi.nlm.nih.gov/pubmed/33972802
http://dx.doi.org/10.1038/s41593-021-00850-4
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author Eiselt, Anne-Kathrin
Chen, Susu
Chen, Jim
Arnold, Jon
Kim, Tahnbee
Pachitariu, Marius
Sternson, Scott M.
author_facet Eiselt, Anne-Kathrin
Chen, Susu
Chen, Jim
Arnold, Jon
Kim, Tahnbee
Pachitariu, Marius
Sternson, Scott M.
author_sort Eiselt, Anne-Kathrin
collection PubMed
description Physiological need states direct decision-making towards re-establishing homeostasis. Using a two-alternative-forced-choice task for mice that models elements of human decisions, we found that varying hunger and thirst states caused need-inappropriate choices, such as food-seeking when thirsty. These results show limits on interoceptive knowledge of hunger and thirst states to guide decision-making. Instead, need states were identified after food and water consumption by outcome evaluation, which depended on medial prefrontal cortex.
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spelling pubmed-82547952021-11-10 Hunger or thirst state-uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making Eiselt, Anne-Kathrin Chen, Susu Chen, Jim Arnold, Jon Kim, Tahnbee Pachitariu, Marius Sternson, Scott M. Nat Neurosci Article Physiological need states direct decision-making towards re-establishing homeostasis. Using a two-alternative-forced-choice task for mice that models elements of human decisions, we found that varying hunger and thirst states caused need-inappropriate choices, such as food-seeking when thirsty. These results show limits on interoceptive knowledge of hunger and thirst states to guide decision-making. Instead, need states were identified after food and water consumption by outcome evaluation, which depended on medial prefrontal cortex. 2021-05-10 2021-07 /pmc/articles/PMC8254795/ /pubmed/33972802 http://dx.doi.org/10.1038/s41593-021-00850-4 Text en http://www.nature.com/authors/editorial_policies/license.html#termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Eiselt, Anne-Kathrin
Chen, Susu
Chen, Jim
Arnold, Jon
Kim, Tahnbee
Pachitariu, Marius
Sternson, Scott M.
Hunger or thirst state-uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making
title Hunger or thirst state-uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making
title_full Hunger or thirst state-uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making
title_fullStr Hunger or thirst state-uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making
title_full_unstemmed Hunger or thirst state-uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making
title_short Hunger or thirst state-uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making
title_sort hunger or thirst state-uncertainty is resolved by outcome evaluation in medial prefrontal cortex to guide decision-making
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254795/
https://www.ncbi.nlm.nih.gov/pubmed/33972802
http://dx.doi.org/10.1038/s41593-021-00850-4
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