Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes

The balanced functionality of cellular proteostatic modules is central to both proteome stability and mitochondrial physiology; thus, the age-related decline of proteostasis also triggers mitochondrial dysfunction, which marks multiple degenerative disorders. Non-functional mitochondria are removed...

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Detalles Bibliográficos
Autores principales: Gumeni, Sentiljana, Papanagnou, Eleni-Dimitra, Manola, Maria S., Trougakos, Ioannis P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254809/
https://www.ncbi.nlm.nih.gov/pubmed/34218254
http://dx.doi.org/10.1038/s41419-021-03952-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8254809/
https://www.ncbi.nlm.nih.gov/pubmed/34218254
http://dx.doi.org/10.1038/s41419-021-03952-w

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