A dual inhibitor overcomes drug-resistant FLT3-ITD acute myeloid leukemia

FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor prognosis. Multiple FLT3 inhibitors are in various stages of clinical evaluation. However, resistance to FLT3 inhibitors resulting from acquired point mutations in tyros...

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Detalles Bibliográficos
Autores principales: Wang, Peihong, Xiao, Xinhua, Zhang, Yuyin, Zhang, Baoyuan, Li, Donghe, Liu, Mingzhu, Xie, Xi, Liu, Chenxuan, Liu, Ping, Ren, Ruibao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255005/
https://www.ncbi.nlm.nih.gov/pubmed/34217323
http://dx.doi.org/10.1186/s13045-021-01098-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255005/
https://www.ncbi.nlm.nih.gov/pubmed/34217323
http://dx.doi.org/10.1186/s13045-021-01098-y

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