Cargando…
A dual inhibitor overcomes drug-resistant FLT3-ITD acute myeloid leukemia
FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor prognosis. Multiple FLT3 inhibitors are in various stages of clinical evaluation. However, resistance to FLT3 inhibitors resulting from acquired point mutations in tyros...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255005/ https://www.ncbi.nlm.nih.gov/pubmed/34217323 http://dx.doi.org/10.1186/s13045-021-01098-y |