Cargando…

System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2

The worldwide circulation of different viruses coupled with the increased frequency and diversity of new outbreaks, strongly highlight the need for new antiviral drugs to quickly react against potential pandemic pathogens. Broad-spectrum antiviral agents (BSAAs) represent the ideal option for a prom...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vicenti, Ilaria, Martina, Maria Grazia, Boccuto, Adele, De Angelis, Marta, Giavarini, Giorgia, Dragoni, Filippo, Marchi, Serena, Trombetta, Claudia Maria, Crespan, Emmanuele, Maga, Giovanni, Eydoux, Cecilia, Decroly, Etienne, Montomoli, Emanuele, Nencioni, Lucia, Zazzi, Maurizio, Radi, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier Masson SAS. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255191/ https://www.ncbi.nlm.nih.gov/pubmed/34273661 http://dx.doi.org/10.1016/j.ejmech.2021.113683

Ejemplares similares

Bithiazole Inhibitors of Phosphatidylinositol 4‐Kinase (PI4KIIIβ) as Broad‐Spectrum Antivirals Blocking the Replication of SARS‐CoV‐2, Zika Virus, and Human Rhinoviruses
por: Grazia Martina, Maria, et al.
Publicado: (2021)

Zika Virus in West Africa: A Seroepidemiological Study between 2007 and 2012
por: Marchi, Serena, et al.
Publicado: (2020)

Multicomponent Synthesis of Diaminopurine and Guanine PNA’s Analogues Active against Influenza A Virus from Prebiotic Compounds
por: Bizzarri, Bruno Mattia, et al.
Publicado: (2022)

BNT162b2 SARS-CoV-2 Vaccination Elicits High Titers of Neutralizing Antibodies to Both B.1 and P.1 Variants in Previously Infected and Uninfected Subjects
por: Vicenti, Ilaria, et al.
Publicado: (2021)

The second dose of the BNT162b2 mRNA vaccine does not boost SARS-CoV-2 neutralizing antibody response in previously infected subjects
por: Vicenti, Ilaria, et al.
Publicado: (2021)

Single-dose BNT162b2 mRNA COVID-19 vaccine significantly boosts neutralizing antibody response in health care workers recovering from asymptomatic or mild natural SARS-CoV-2 infection
por: Vicenti, Ilaria, et al.
Publicado: (2021)

Faster decay of neutralizing antibodies in never infected than previously infected healthcare workers three months after the second BNT162b2 mRNA COVID-19 vaccine dose
por: Vicenti, Ilaria, et al.
Publicado: (2021)

Serum Neutralizing Activity against B.1.1.7, B.1.351, and P.1 SARS-CoV-2 Variants of Concern in Hospitalized COVID-19 Patients
por: Trombetta, Claudia Maria, et al.
Publicado: (2021)

Nanomechanics of negatively supercoiled diaminopurine-substituted DNA
por: Salerno, Domenico, et al.
Publicado: (2021)

Decreased neutralization of the Eta SARS-CoV-2 variant by sera of previously infected and uninfected vaccinated individuals
por: Boccuto, Adele, et al.
Publicado: (2021)

Time Course of Neutralizing Antibody in Health Care Workers With Mild or Asymptomatic COVID-19 Infection
por: Vicenti, Ilaria, et al.
Publicado: (2021)

SARS-CoV-2 Infection of Human Ovarian Cells: A Potential Negative Impact on Female Fertility
por: Luongo, Francesca P., et al.
Publicado: (2022)

Surveillance for Severe Acute Respiratory Infections among Hospitalized Subjects from 2015/2016 to 2019/2020 Seasons in Tuscany, Italy
por: Manini, Ilaria, et al.
Publicado: (2021)

A chemical synthesis of LNA-2,6-diaminopurine riboside, and the influence of 2′-O-methyl-2,6-diaminopurine and LNA-2,6-diaminopurine ribosides on the thermodynamic properties of 2′-O-methyl RNA/RNA heteroduplexes
por: Pasternak, Anna, et al.
Publicado: (2007)

Error-free bypass of 2-hydroxyadenine by human DNA polymerase λ with Proliferating Cell Nuclear Antigen and Replication Protein A in different sequence contexts
por: Crespan, Emmanuele, et al.
Publicado: (2007)

Sofosbuvir Selects for Drug-Resistant Amino Acid Variants in the Zika Virus RNA-Dependent RNA-Polymerase Complex In Vitro
por: Boccuto, Adele, et al.
Publicado: (2021)

Microhomology-mediated DNA strand annealing and elongation by human DNA polymerases λ and β on normal and repetitive DNA sequences
por: Crespan, Emmanuele, et al.
Publicado: (2012)

Exploiting the Nucleotide Substrate Specificity of Repair DNA Polymerases To Develop Novel Anticancer Agents
por: Crespan, Emmanuele, et al.
Publicado: (2011)

High Flexibility of RNaseH2 Catalytic Activity with Respect to Non-Canonical DNA Structures
por: Dede, Maria, et al.
Publicado: (2021)

In Vitro Anti-SARS-CoV-2 Activity of Selected Metal Compounds and Potential Molecular Basis for Their Actions Based on Computational Study
por: Cirri, Damiano, et al.
Publicado: (2021)

DNA Polymerases λ and β: The Double-Edged Swords of DNA Repair
por: Mentegari, Elisa, et al.
Publicado: (2016)

CYTOLOGICAL STUDIES ON THE ANTIMETABOLITE ACTION OF 2,6-DIAMINOPURINE IN VICIA FABA ROOTS
por: Setterfield, George, et al.
Publicado: (1955)

2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations
por: Trzaska, Carole, et al.
Publicado: (2020)

2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions
por: Szabla, Rafał, et al.
Publicado: (2021)

Efficacy of Licensed Monoclonal Antibodies and Antiviral Agents against the SARS-CoV-2 Omicron Sublineages BA.1 and BA.2
por: Fiaschi, Lia, et al.
Publicado: (2022)

Di-μ-but-2-enoato-bis[diaquabis(but-2-enoato)neodymium(III)] 2,6-diaminopurine disolvate
por: Atria, Ana María, et al.
Publicado: (2011)

Comparable Post-Vaccination Decay of Neutralizing Antibody Response to Wild-Type and Delta SARS-CoV-2 Variant in Healthcare Workers Recovered from Mild or Asymptomatic Infection
por: Vicenti, Ilaria, et al.
Publicado: (2022)

Elimination of congenital rubella: a seroprevalence study of pregnant women and women of childbearing age in Italy
por: Marchi, Serena, et al.
Publicado: (2019)

Toxoplasma gondii in women of childbearing age and during pregnancy: seroprevalence study in Central and Southern Italy from 2013 to 2017
por: Fanigliulo, Daniela, et al.
Publicado: (2020)

Seroprevalence of antibodies to cytomegalovirus in pregnant women in the Apulia region (Italy)
por: TROMBETTA, CLAUDIA MARIA, et al.
Publicado: (2021)

A Chemical Approach to Introduce 2,6-Diaminopurine and 2-Aminoadenine Conjugates into Oligonucleotides without Need for Protecting Groups
por: Madaoui, Mimouna, et al.
Publicado: (2022)

Impact of SARS-CoV-2 omicron BA.1 and delta AY.4.2 variants on the neutralization by sera of patients treated with different authorized monoclonal antibodies
por: Dragoni, Filippo, et al.
Publicado: (2022)

Measles in pregnancy: a threat for Italian women?
por: Marchi, Serena, et al.
Publicado: (2019)

Influenza Viruses and Vaccines: The Role of Vaccine Effectiveness Studies for Evaluation of the Benefits of Influenza Vaccines
por: Trombetta, Claudia Maria, et al.
Publicado: (2022)

Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases β and λ
por: Crespan, Emmanuele, et al.
Publicado: (2007)

Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X
por: Brai, Annalaura, et al.
Publicado: (2019)

Easily Satisfied!
Publicado: (1898)

Epidemiology of herpes simplex virus type 1 and 2 in Italy: a seroprevalence study from 2000 to 2014
por: Marchi, S., et al.
Publicado: (2017)

Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase
por: Brecher, Matthew, et al.
Publicado: (2015)

Broad Host Tropism of Flaviviruses during the Entry Stage
por: Zhang, Yanan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5deqerm4gvgr2ru52sd4ofcrqk