Cargando…

OMRT-5. Therapy-induced reprogramming drives glioma vascular transdifferentiation and recurrence

Therapy-resistant glioma cells elicit remarkable phenotypic plasticity leading to aggressive tumor recurrence. Here, we used single-cell and whole transcriptomic sequencing to uncover that radiation treatment induces a dynamic shift in functional states of glioma cells allowing for acquisition of ei...

Descripción completa

Detalles Bibliográficos
Autores principales:	Muthukrishnan, Sree Deepthi, Kawaguchi, Riki, Nair, Pooja, Prasad, Rachna, Qin, Yue, Condro, Michael, Wang, Qing, Alvarado, Alvaro, Kornblum, Harley
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Supplement Abstracts
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255432/ http://dx.doi.org/10.1093/noajnl/vdab070.030

Ejemplares similares

OTEH-8. Pathway-based approach reveals sensitivity to radiation when targeting E2F1 in Glioblastoma
por: Alvarado, Alvaro, et al.
Publicado: (2021)

OMRT-6. Optimizing MDM2 inhibition for the treatment of high-grade glioma
por: Rendo, Veronica, et al.
Publicado: (2021)

P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells
por: Muthukrishnan, Sree Deepthi, et al.
Publicado: (2022)

OMRT-13. Delivery of Ubidecarenone (BPM 31510) to mitochondria effectuates metabolic reprogramming and redox activated apoptosis in Glioblastoma
por: Sarangarajan, Rangaprasad, et al.
Publicado: (2021)

OMRT-8. Precision targeting of cellular pathways with complementary diagnostics
por: Siddaway, Robert, et al.
Publicado: (2021)

OMRT-3. Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment
por: Varn, Frederick, et al.
Publicado: (2021)

OMRT-11. The effect of microenvironment on glioblastoma stem cells therapeutic resistance
por: Turnsek, Tamara Lah, et al.
Publicado: (2021)

OMRT-7. Angiogenesis inhibitors strongly synergize with therapeutics targeting tumor metabolism
por: Khadka, Sunada
Publicado: (2021)

OMRT-12. Nanoparticle-based CRISPR-Cas9 delivery for anti-glioblastoma immunotherapy
por: Aguilar, Rocio, et al.
Publicado: (2021)

OMRT-1. Cannabidiol converts NFKB into a tumor-suppressor in glioblastoma with defined antioxidative properties
por: Volmar, Marie, et al.
Publicado: (2021)

Pathway-based Approach Reveals Differential Sensitivity to E2F1 Inhibition in Glioblastoma
por: Alvarado, Alvaro G., et al.
Publicado: (2022)

OMRT-14. Small molecule circadian clock compounds exhibit potential as a novel therapy paradigm for glioblastoma
por: Chan, Priscilla, et al.
Publicado: (2021)

OMRT-15. Multidisciplinary management of non-small cell lung cancer patients with leptomeningeal metastasis in the TKI era
por: Chen, Kuan-Yu, et al.
Publicado: (2021)

OMRT-2. Liquid biopsy for patient stratification and monitoring of dacomitinib clinical trial in patients with EGFR amplified recurrent glioblastoma
por: Yekula, Anudeep, et al.
Publicado: (2021)

OMRT-9. Effect of Pre-Operative Stereotactic Radiosurgery on Brain Metastasis: Analysis of DNA and RNA Genomic Profiles from Phase-II Clinical Trial NCT03398694
por: Shireman, Jack, et al.
Publicado: (2021)

Reprogramming, oscillations and transdifferentiation in epigenetic landscapes
por: Kaity, Bivash, et al.
Publicado: (2018)

A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration
por: Ghochani, Yasmin, et al.
Publicado: (2022)

Exploring the Mechanisms of Differentiation, Dedifferentiation, Reprogramming and Transdifferentiation
por: Xu, Li, et al.
Publicado: (2014)

Epigenetic Regulation of B Lymphocyte Differentiation, Transdifferentiation, and Reprogramming
por: Barneda-Zahonero, Bruna, et al.
Publicado: (2012)

DDRE-29. DE NOVO PYRIMIDINE SYNTHESIS IS A TARGETABLE VULNERABILITY IN IDH-MUTANT GLIOMA
por: Shi, Diana D, et al.
Publicado: (2021)

Editorial: Transdetermination, transdifferentiation, and reprogramming of cells: In vitro and in vivo strategies
por: Cieslar-Pobuda, Artur, et al.
Publicado: (2023)

Direct cellular reprogramming and transdifferentiation of fibroblasts on wound healing—Fantasy or reality?
por: Du, Juan, et al.
Publicado: (2023)

Brain Tumor Stem Cells as Therapeutic Targets in Models of Glioma
por: Laks, Dan Richard, et al.
Publicado: (2010)

Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand?
por: Ebert, Antje D, et al.
Publicado: (2015)

Dental-derived cells for regenerative medicine: stem cells, cell reprogramming, and transdifferentiation
por: Cho, Young-Dan, et al.
Publicado: (2022)

BT-1 An autopsy case of multicentric malignant glioma, H3K27M mutant
por: Hayashi, Nobuhide, et al.
Publicado: (2021)

Concurrent BMP7 and FGF9 signalling governs AP-1 function to promote self-renewal of nephron progenitor cells
por: Muthukrishnan, Sree Deepthi, et al.
Publicado: (2015)

Nephron progenitor cell death elicits a limited compensatory response associated with interstitial expansion in the neonatal kidney
por: Muthukrishnan, Sree Deepthi, et al.
Publicado: (2018)

Transient Acquisition of Pluripotency During Somatic Cell Transdifferentiation with iPSC Reprogramming Factors
por: Maza, Itay, et al.
Publicado: (2015)

Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming
por: Francesconi, Mirko, et al.
Publicado: (2019)

Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming
por: Bellon, Alfredo, et al.
Publicado: (2018)

Bradykinin, as a Reprogramming Factor, Induces Transdifferentiation of Brain Astrocytes into Neuron-like Cells
por: Lee, Tsong-Hai, et al.
Publicado: (2021)

Identification of an Efficient Gene Expression Panel for Glioblastoma Classification
por: Crisman, Thomas J., et al.
Publicado: (2016)

Transdifferentiation is a driving force of regeneration in Halisarca dujardini (Demospongiae, Porifera)
por: Borisenko, Ilya E., et al.
Publicado: (2015)

Behavioral Characteristics of Children with High Functioning Pervasive Developmental Disorders during a Game
por: Kawaguchi, Hideo, et al.
Publicado: (2010)

Is transdifferentiation in trouble?
por: Wells, William A.
Publicado: (2002)

Cell Transdifferentiation and Reprogramming in Disease Modeling: Insights into the Neuronal and Cardiac Disease Models and Current Translational Strategies
por: Kalra, Rajkumar Singh, et al.
Publicado: (2021)

Metabolic Reprogramming in Glioma
por: Strickland, Marie, et al.
Publicado: (2017)

OTEH-10. Evolutionary trajectory of epigenomic of gliomas
por: Malta, Tathiane, et al.
Publicado: (2021)

Decoding vesicle-based precision oncology in gliomas
por: Batool, Syeda Maheen, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_6slh1knqtglp29thfj6hdb133u