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ECOA-5. Integrative 3D spatial characterization of genomic and epigenomic intratumoral heterogeneity in glioblastoma

Treatment failure in glioblastoma is often attributed to intratumoral heterogeneity (ITH), which fosters tumor evolution and selection of therapy-resistant clones. While genomic alterations are known contributors to ITH, emerging studies highlight functional roles for epigenomic ITH which integrates...

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Detalles Bibliográficos
Autores principales: Mathur, Radhika, Wang, Qixuan, Schupp, Patrick, Hilz, Stephanie, Hong, Chibo, Smirnov, Ivan, Lafontaine, Marisa, Nair, Devika, Iyyanaki, Sriranga, Phillips, Joanna, Chang, Susan, Li, Yan, Lupo, Janine, Oldham, Michael, Yue, Feng, Costello, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255440/
http://dx.doi.org/10.1093/noajnl/vdab070.005