OMRT-13. Delivery of Ubidecarenone (BPM 31510) to mitochondria effectuates metabolic reprogramming and redox activated apoptosis in Glioblastoma

GBM is a highly metabolic cancer phenotype that confers sustained growth and evasion of cell death mechanism via mitochondrial dysregulation. Efforts to re-engage mitochondrial metabolism via anti-cancer therapeutics has not been successful. BPM 31510 is a CoQ10-lipid conjugate nanodispersion for de...

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Detalles Bibliográficos
Autores principales: Sarangarajan, Rangaprasad, Nagpal, Seema, Sun, Jiaxin, Diers, Anne, Shah, Punit, Tolstikov, Vladimir, Miller, Gregory, Vishnudas, Vivek, Gesta, Stephane, Kiebish, Michael, Granger, Elder, Narain, Niven, Recht, Lawrence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255450/
http://dx.doi.org/10.1093/noajnl/vdab070.037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255450/
http://dx.doi.org/10.1093/noajnl/vdab070.037

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