Ser(71) Phosphorylation Inhibits Actin-Binding of Profilin-1 and Its Apoptosis-Sensitizing Activity

The essential actin-binding factor profilin-1 (Pfn1) is a non-classical tumor suppressor with the abilities toboth inhibit cellular proliferation and augment chemotherapy-induced apoptosis. Besides actin, Pfn1 interacts with proteins harboring the poly-L-proline (PLP) motifs. Our recent work demonst...

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Detalles Bibliográficos
Autores principales: Wang, Faliang, Zhu, Cuige, Cai, Shirong, Boudreau, Aaron, Kim, Sun-Joong, Bissell, Mina, Shao, Jieya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255618/
https://www.ncbi.nlm.nih.gov/pubmed/34235154
http://dx.doi.org/10.3389/fcell.2021.692269

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255618/
https://www.ncbi.nlm.nih.gov/pubmed/34235154
http://dx.doi.org/10.3389/fcell.2021.692269

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