A Missense Mutation rs781536408 (c.2395G>A) of TYK2 Affects Splicing and Causes Skipping of Exon18 in vivo

TYK2 variants can impact disease onset or progression. In our previous study, we identified abnormal splicing that happened near rs781536408 in the TYK2 gene. The purpose of this research was to examine the effect of the mutation on alternative splicing in vivo and in vitro. Whole exome sequencing w...

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Detalles Bibliográficos
Autores principales: Chen, Suqing, Wu, Peilin, Wu, Bin, Lin, Chenye, Chen, Junhong, Chen, Lishengdan, Lv, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255812/
https://www.ncbi.nlm.nih.gov/pubmed/34234812
http://dx.doi.org/10.3389/fgene.2021.679678

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255812/
https://www.ncbi.nlm.nih.gov/pubmed/34234812
http://dx.doi.org/10.3389/fgene.2021.679678

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