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Invaplex functions as an intranasal adjuvant for subunit and DNA vaccines co-delivered in the nasal cavity of nonhuman primates

Development of intranasal vaccines for HIV-1 and other mucosal pathogens has been hampered by the lack of adjuvants that can be given safely to humans. We have found that an intranasal Shigella vaccine (Invaplex) which is well tolerated in humans can also function as an adjuvant for intranasal prote...

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Detalles Bibliográficos
Autores principales: Camp, Jeremy V., Wilson, Robert L., Singletary, Morgan, Blanchard, James L., Aldovini, Anna, Kaminski, Robert W., Oaks, Edwin V., Kozlowski, Pamela A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8255935/
https://www.ncbi.nlm.nih.gov/pubmed/34258576
http://dx.doi.org/10.1016/j.jvacx.2021.100105