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GRINS: Genetic elements that recode assembly-line polyketide synthases and accelerate their diversification
Assembly-line polyketide synthases (PKSs) are large and complex enzymatic machineries with a multimodular architecture, typically encoded in bacterial genomes by biosynthetic gene clusters. Their modularity has led to an astounding diversity of biosynthesized molecules, many with medical relevance....
Autores principales: | Nivina, Aleksandra, Herrera Paredes, Sur, Fraser, Hunter B., Khosla, Chaitan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256042/ https://www.ncbi.nlm.nih.gov/pubmed/34162709 http://dx.doi.org/10.1073/pnas.2100751118 |
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