Simultaneous Determination of a Novel PD-L1 Inhibitor, IMMH-010, and Its Active Metabolite, YPD-29B, in Rat Biological Matrices by Polarity-Switching Liquid Chromatography-Tandem Mass Spectrometry: Application to ADME Studies

IMMH-010 is a prodrug of YPD-29B, which is a novel PD-L1 inhibitor. A specific and sensitive LC-MS/MS method with polarity switching was developed and validated for the simultaneous determination of IMMH-010 and YPD-29B in rat plasma, liver, brain, urine and fecal samples. Method validation was inve...

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Detalles Bibliográficos
Autores principales: Jiang, Jianwei, Zou, Xiaowen, Liu, Yuke, Liu, Xiao, Dong, Kai, Yao, Xiaoqing, Feng, Zhiqiang, Chen, Xiaoguang, Sheng, Li, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256334/
https://www.ncbi.nlm.nih.gov/pubmed/34234673
http://dx.doi.org/10.3389/fphar.2021.677120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256334/
https://www.ncbi.nlm.nih.gov/pubmed/34234673
http://dx.doi.org/10.3389/fphar.2021.677120

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