Mass Spectrometry-Based De Novo Sequencing of Monoclonal Antibodies Using Multiple Proteases and a Dual Fragmentation Scheme

[Image: see text] Antibody sequence information is crucial to understanding the structural basis for antigen binding and enables the use of antibodies as therapeutics and research tools. Here, we demonstrate a method for direct de novo sequencing of monoclonal IgG from the purified antibody products...

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Detalles Bibliográficos
Autores principales: Peng, Weiwei, Pronker, Matti F., Snijder, Joost
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256418/
https://www.ncbi.nlm.nih.gov/pubmed/34121409
http://dx.doi.org/10.1021/acs.jproteome.1c00169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256418/
https://www.ncbi.nlm.nih.gov/pubmed/34121409
http://dx.doi.org/10.1021/acs.jproteome.1c00169

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