Is more better? An analysis of toxicity and response outcomes from dose-finding clinical trials in cancer

BACKGROUND: The overwhelming majority of dose-escalation clinical trials use methods that seek a maximum tolerable dose, including rule-based methods like the 3+3, and model-based methods like CRM and EWOC. These methods assume that the incidences of efficacy and toxicity always increase as dose is...

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Detalles Bibliográficos
Autores principales: Brock, Kristian, Homer, Victoria, Soul, Gurjinder, Potter, Claire, Chiuzan, Cody, Lee, Shing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256624/
https://www.ncbi.nlm.nih.gov/pubmed/34225682
http://dx.doi.org/10.1186/s12885-021-08440-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256624/
https://www.ncbi.nlm.nih.gov/pubmed/34225682
http://dx.doi.org/10.1186/s12885-021-08440-0

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