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Is more better? An analysis of toxicity and response outcomes from dose-finding clinical trials in cancer
BACKGROUND: The overwhelming majority of dose-escalation clinical trials use methods that seek a maximum tolerable dose, including rule-based methods like the 3+3, and model-based methods like CRM and EWOC. These methods assume that the incidences of efficacy and toxicity always increase as dose is...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256624/ https://www.ncbi.nlm.nih.gov/pubmed/34225682 http://dx.doi.org/10.1186/s12885-021-08440-0 |