Triosephosphate isomerase: the perfect enzyme, but how does it work?

Insights are offered on the study by Kelpšas et al. [ IUCrJ (2021). 8, 633–643], who have combined neutron and X-ray crystallography then QM (quantum mechanics) calculations on triosephosphate isomerase (TIM). The authors dissect three possible enzyme mechanisms of TIM that have arisen in the decade...

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Detalles Bibliográficos
Autor principal: Helliwell, John R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2021
Materias:
Scientific Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256717/
https://www.ncbi.nlm.nih.gov/pubmed/34257998
http://dx.doi.org/10.1107/S205225252100573X
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author Helliwell, John R.
author_facet Helliwell, John R.
author_sort Helliwell, John R.
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description Insights are offered on the study by Kelpšas et al. [ IUCrJ (2021). 8, 633–643], who have combined neutron and X-ray crystallography then QM (quantum mechanics) calculations on triosephosphate isomerase (TIM). The authors dissect three possible enzyme mechanisms of TIM that have arisen in the decades since the first X-ray crystal structure of this enzyme was published in 1975.
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spelling pubmed-82567172021-07-12 Triosephosphate isomerase: the perfect enzyme, but how does it work? Helliwell, John R. IUCrJ Scientific Commentaries Insights are offered on the study by Kelpšas et al. [ IUCrJ (2021). 8, 633–643], who have combined neutron and X-ray crystallography then QM (quantum mechanics) calculations on triosephosphate isomerase (TIM). The authors dissect three possible enzyme mechanisms of TIM that have arisen in the decades since the first X-ray crystal structure of this enzyme was published in 1975. International Union of Crystallography 2021-06-30 /pmc/articles/PMC8256717/ /pubmed/34257998 http://dx.doi.org/10.1107/S205225252100573X Text en © John R. Helliwell 2021 https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Scientific Commentaries
Helliwell, John R.
Triosephosphate isomerase: the perfect enzyme, but how does it work?
title Triosephosphate isomerase: the perfect enzyme, but how does it work?
title_full Triosephosphate isomerase: the perfect enzyme, but how does it work?
title_fullStr Triosephosphate isomerase: the perfect enzyme, but how does it work?
title_full_unstemmed Triosephosphate isomerase: the perfect enzyme, but how does it work?
title_short Triosephosphate isomerase: the perfect enzyme, but how does it work?
title_sort triosephosphate isomerase: the perfect enzyme, but how does it work?
topic Scientific Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256717/
https://www.ncbi.nlm.nih.gov/pubmed/34257998
http://dx.doi.org/10.1107/S205225252100573X
work_keys_str_mv AT helliwelljohnr triosephosphateisomerasetheperfectenzymebuthowdoesitwork

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