Competition for DNA binding between paralogous transcription factors determines their genomic occupancy and regulatory functions

Most eukaryotic transcription factors (TFs) are part of large protein families, with members of the same family (i.e., paralogous TFs) recognizing similar DNA-binding motifs but performing different regulatory functions. Many TF paralogs are coexpressed in the cell and thus can compete for target si...

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Detalles Bibliográficos
Autores principales: Zhang, Yuning, Ho, Tiffany D., Buchler, Nicolas E., Gordân, Raluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256859/
https://www.ncbi.nlm.nih.gov/pubmed/33975875
http://dx.doi.org/10.1101/gr.275145.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256859/
https://www.ncbi.nlm.nih.gov/pubmed/33975875
http://dx.doi.org/10.1101/gr.275145.120

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