Selection and thermostability suggest G-quadruplexes are novel functional elements of the human genome

Approximately 1% of the human genome has the ability to fold into G-quadruplexes (G4s)—noncanonical strand-specific DNA structures forming at G-rich motifs. G4s regulate several key cellular processes (e.g., transcription) and have been hypothesized to participate in others (e.g., firing of replicat...

Descripción completa

Detalles Bibliográficos
Autores principales: Guiblet, Wilfried M., DeGiorgio, Michael, Cheng, Xiaoheng, Chiaromonte, Francesca, Eckert, Kristin A., Huang, Yi-Fei, Makova, Kateryna D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256861/
https://www.ncbi.nlm.nih.gov/pubmed/34187812
http://dx.doi.org/10.1101/gr.269589.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256861/
https://www.ncbi.nlm.nih.gov/pubmed/34187812
http://dx.doi.org/10.1101/gr.269589.120

Ejemplares similares