Genome-wide profiling reveals functional interplay of DNA sequence composition, transcriptional activity, and nucleosome positioning in driving DNA supercoiling and helix destabilization in C. elegans

DNA topology and alternative DNA structures are implicated in regulating diverse biological processes. Although biomechanical properties of these structures have been studied extensively in vitro, characterization in vivo, particularly in multicellular organisms, is limited. We devised new methods t...

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Detalles Bibliográficos
Autores principales: Krassovsky, Kristina, Ghosh, Rajarshi P., Meyer, Barbara J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256864/
https://www.ncbi.nlm.nih.gov/pubmed/34168009
http://dx.doi.org/10.1101/gr.270082.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256864/
https://www.ncbi.nlm.nih.gov/pubmed/34168009
http://dx.doi.org/10.1101/gr.270082.120

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