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The loss of heterochromatin is associated with multiscale three-dimensional genome reorganization and aberrant transcription during cellular senescence

Heterochromatin remodeling is critical for various cell processes. In particular, the “loss of heterochromatin” phenotype in cellular senescence is associated with the process of aging and age-related disorders. Although biological processes of senescent cells, including senescence-associated hetero...

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Detalles Bibliográficos
Autores principales: Zhang, Xianglin, Liu, Xuehui, Du, Zhenhai, Wei, Lei, Fang, Huan, Dong, Qiongye, Niu, Jing, Li, Yanda, Gao, Juntao, Zhang, Michael Q., Xie, Wei, Wang, Xiaowo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8256869/
https://www.ncbi.nlm.nih.gov/pubmed/34140314
http://dx.doi.org/10.1101/gr.275235.121